Location: I-255 and I-64, Caseyville Reassurance shield after the I-64 junction. Location: I-255 and State St, Caseyville A couple miles later, we’ll approach Route 15. Location: I-255 and Missouri Ave, Centreville In a quarter mile, we’ll approach Route 15. Location: I-255 and Missouri Ave, Centreville Follow 15 west into East St. Louis. Location: I-255 and … Continue reading U.S. Route 50, I-64/I-255 to IL-15